Download Acute Stroke: Bench to Bedside (Neurological Disease and by Anish Bhardwaj, Nabil J. Alkayed, Jeffrey R. Kirsch, Richard PDF

By Anish Bhardwaj, Nabil J. Alkayed, Jeffrey R. Kirsch, Richard J. Traystman

Because the 3rd prime reason for demise within the usa, stroke bills for one in each fifteen deaths and is the main reason for incapacity within the state. Compiled by way of a popular editorial workforce, this reference bridges the space among easy technological know-how and sufferer care protocols, and collects forty three expertly written chapters that variety from laboratory-based examine on animal types to the development, mechanisms, remedy, and analysis of ailments reminiscent of subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH), focal ischemic stroke, and worldwide cerebral ischemia.

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Extra info for Acute Stroke: Bench to Bedside (Neurological Disease and Therapy)

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Studies performed with this model were designed to test the potential protective effect of overexpressed superoxide dismutase in transgenic mice. Advantages of this model include a relatively low cost and the ability to use transgenic mice. Disadvantages include a high mortality rate, moderate vasospasm, lack of standardization of hemorrhagic volume, and interobserver variability when measuring MCA diameters. A modified technique for intracisternal injection has been reported (123) in which the femoral artery is cannulated and 60 mL of blood is withdrawn and reinjected into the cisterna magna.

Macdonald RL, Weir BK, Runzer TD, et al. Etiology of cerebral vasospasm in primates. J Neurosurg 1991; 75:415 – 424. 46. Pluta RM, Deka-Starosta A, Zauner A, Morgan JK, Muraszko KM, Oldfield EH. Neuropeptide Y in the primate model of subarachnoid hemorrhage. J Neurosurg 1992; 77:417–423. 47. Pluta RM, Zauner A, Morgan JK, Muraszko KM, Oldfield EH. Is vasospasm related to proliferative arteriopathy? J Neurosurg 1992; 77:740–748. 48. Macdonald RL, Weir BK, Runzer TD, Grace MG, Poznansky MJ. Effect of intrathecal superoxide dismutase and catalase on oxyhemoglobin-induced vasospasm in monkeys.

J Neurosurg Anesthesiol 1998; 10:171–177. 116. Schwartz AY, Masago A, Sehba FA, Bederson JB. Experimental models of subarachnoid hemorrhage in the rat: a refinement of the endovascular filament model. J Neurosci Methods 2000; 96:161–167. 117. Gules I, Satoh M, Clower BR, Nanda A, Zhang JH. Comparison of three rat models of cerebral vasospasm. Am J Physiol Heart Circ Physiol 2002; 283:H2551–H2559. 118. Okada T, Harada T, Bark DH, Mayberg MR. A rat femoral artery model for vasospasm. Neurosurgery 1990; 27:349–356.

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