Download Annual Update in Intensive Care and Emergency Medicine 2016 by Jean-Louis Vincent PDF

By Jean-Louis Vincent

The yearly replace compiles the latest advancements in experimental and medical examine and perform in a single entire reference booklet. The chapters are written through good famous specialists within the box of extensive care and emergency drugs. it really is addressed to every person thinking about inner medication, anesthesia, surgical procedure, pediatrics, in depth care and emergency medication.

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Curr Opin Pulm Med 20:233–241 24. Memish ZA, Al-Tawfiq JA, Assiri A et al (2014) Middle East respiratory syndrome coronavirus disease in children. Pediatr Infect Dis J 33:904–906 25. Ajlan AM, Ahyad RA, Jamjoom LG, Alharthy A, Madani TA (2014) Middle East respiratory syndrome coronavirus (MERS-CoV) infection: chest CT findings. AJR Am J Roentgenol 203:782–787 26. Arabi YM, Arifi AA, Balkhy HH et al (2014) Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection.

Several RCTs have compared antibiotic courses prescribed as usual care with an approach focusing on antibiotic stopping, using algorithms taking into account the evolution of biomarkers or clinical parameters. Serial measurements of procalcitonin (PCT) with an algorithm recommending that antibiotics be stopped when PCT concentrations decrease below a certain threshold or percentage from its peak value, can be used to reduce the duration of the antibiotic course to a median of 6 days [25]. When PCT is not available, serial clinical evaluations may achieve the same goal, at least for respiratory infections [26].

Not surprisingly, three lines of evidence support the potential deleterious role of plasmacytoid dendritic cells: Plasmacytoid Dendritic Cells in Severe Influenza Infection 27 (1) In a murine model of influenza infection, plasmacytoid dendritic cell depletion improved macrophage recruitment and enhanced inflammatory response (tumor necrosis factor (TNF)-˛/interleukin (IL)-6 increased 5–35 fold), suggesting that plasmacytoid dendritic cells may have a restrictive role in the inflammatory response of macrophages [16].

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