Download Birth, Distress and Disease: Placental-Brain Interactions by Michael L. Power, Jay Schulkin PDF

By Michael L. Power, Jay Schulkin

This quantity examines the function of steroids and peptides within the rules of being pregnant and being pregnant final result, in addition to their long term results. while pregnant the placenta acts as a important regulator and coordinator of maternal and fetal body structure, and on the onset of work, via its construction and law of steroids and peptides. Perturbations to this regulatory process may end up in bad being pregnant consequence, reminiscent of preterm delivery and coffee beginning weight. The induction and suppression of peptides by means of steroids seems to be key to regulatory functionality in either mind and placenta.

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Extra info for Birth, Distress and Disease: Placental-Brain Interactions

Sample text

Both prostaglandin F2 (PGF2) and E2 (PGE2) increases the CRH concentration in the culture medium 22 F. Petraglia et al. 2 Brain The mechanisms stimulating CRF release from medial basal hypothalamus are in part chemically identical to those operating in the human placenta. PGF2 and PGE2, norepinephrine (Nepi), acetylcholine (Ach), angiotensin II (AII), arginine vasopressin (AVP), stimulate CRF in hypothalamus, as well as in placental cells. On the contrary, the effect of OT on CRF and HPA hormones in human placenta, is different being stimulatory.

1988). The effect resembles the neuroendocrine findings showing OT active on hypothalamic CRH and on pituitary POMC-related peptides, participating in the stress-induced events. The similarity between placental ACTH regulation and the brain CRH/ACTH system is also confirmed by the evidence that the addition of neuropeptide Y (NPY), IL-1, arginine vasopressin, angiotensin II, norepinephrine, or acetylcholine increase CRH release. 2 Oxytocin The OT is a neurophyseal hormone composed of nine amino acids, synthesized in the hypothalamus and stored in the neurohypophysis, where it acts as a neurotransmitter involved in sexual and maternal behavior (Acher and Chauvet, 1995).

It is not known whether this deranged secretion is part of the primary pathophysiology of these conditions or occurs as a secondary response to the increased vascular resistance in abnormal pregnancies. The concentration of CRH in the fetal circulation is significantly increased in pregnancies complicated by abnormal umbilical artery flow velocity waveforms, thus representing a stressresponsive compensatory mechanism in the human placenta. Peptide signaling and fetal/maternal endocrinology Neurohormones produced by human placenta, decidua and fetal membranes are secreted into maternal and fetal circulation, and amniotic fluid.

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