By R. Schindler (auth.), Mrs. Rosemarie Schindler (eds.)
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Extra resources for Ciclosporin in Autoimmune Diseases: 1st International Symposium, Basle, March 18–20, 1985
Science 226: 1439-1441 16. FideIus RK, Laughter AH, Twoney JJ, Taffet SM, Haddox MK (1984) The effeet of cyclosporine on ornithine decarboxylase induction with mitogens, antigens, and Iymphokines. Transplantation 37:383-387 17. Granelli-Piperno A, Inaba K, Steinman RM (1984) Stimulation of Lymphokine Release from T Lymphoblasts. J Exp Med 160:1792 -1802 The Mechanism of Action ofCielosporin: A Continuing Puzzle 18. Handschumacher ER, Harding MW, Rice J, Drugge Rl (1984) Cyelophilin: A Specific Cytosolic Binding Protein for Cyelospoin A.
In contrast, HPLC measures the parent compound alone. CyA has been most extensively measured in the serum compartment. Distribution between serum and red cell compartments is temperature-dependent, so 40 that at 4 ac or 22 ac a 20% reduetion in measurable CyA oeeurs within the serum eompartment after approximately 20 minutes, after whieh time equilibration is eomplete. Attempts to correet for this by ineubation of the blood sample at 37 ac produce an error, owing to further partitioning of CyA into the serum compartment accompanying progressive erythrocyte lysis.
Shennib A, Padilla-Longoria R, Chiu RCJ, Mulder DS (1982) Preservation of alveolar 55. 56. 57. 58. 59. 60. 61. maerophage funetion during immunosuppression: Cyelosporin A versus Methylprednisolone. Surgieal Forum 33:338-341 Simons JW, Noga SJ, Colombani PM, Coffey DS, Hess AD: Cyelosporin A induees alterations in the nuelear morphology of human mononuelear leukoeytes. J Cell Bioehem (in press) Suthanthiran M, Evelyn M, Rubin AL, Stenzel KR (1984) A reappraisal of the effeets of monoelonal antibodies direeted at T eell differentiation antigens.